Weekly review: Individualized TRT, acetaminophen safety reaffirmed, and more

Thank you for visiting the Contemporary OB/GYN website. Take a look at some of our top stories from the past week (Monday, June 1, to Friday, June 5, 2026) and click on each link to read and watch anything you may have missed.

FDA approves cefepime and zidebactam intravenous antibiotic to treat adults with cUTI

On June 1, 2026, Wockhardt announced that the FDA has approved cefepime and zidebactam (ZAYNICH; Wockhardt), a novel intravenous antibiotic designed to treat adults with complicated urinary tract infections (cUTI), including pyelonephritis, caused by susceptible Gram-negative pathogens.

Full approval details.

Individualized TRT demonstrates broad symptom improvements beyond sexual function

Testosterone replacement therapy (TRT) in women may offer multidimensional symptom improvement extending beyond sexual function, according to Melissa Loseke, DO, Medical Director, Joi+Blokes, Omaha, Nebraska, highlighting findings from a retrospective study published in Personalized Medicine.

“From a general categorical perspective, beyond sexual function, which I think is what a lot of people think of when we start talking testosterone… across 8 domains, we really saw some improvements. Energy and mood, which were 2 of the biggest ones, which can include depression and irritability, obviously the sexual interest, focus, and concentration, which leads to memory improvements as well, which also can lead to overall quality of life improvements, but also saw some improvements from a cardiometabolic standpoint, with a decline in the triglyceride levels,” said Loseke.

Watch the full interview here.

Acetaminophen remains first-line medication for pain, fever in pregnancy, SMFM says

Acetaminophen is often utilized during pregnancy, with large surveys indicating that up to 65% of pregnant individuals take the medication at some point, primarily to treat headaches and fevers.

In an updated clinical guidance statement published on June 1, 2026, in Pregnancy, the Society for Maternal-Fetal Medicine (SMFM) reaffirmed that acetaminophen remains the recommended first-line medication for managing pain and fever during pregnancy.

Click here for full details.

Nitrofurantoin outperformed fosfomycin for uncomplicated UTIs in randomized trial

UTIs remain one of the most common bacterial infections among women, with clinical guidelines often recommending antibiotics such as nitrofurantoin, fosfomycin, and pivmecillinam. However, direct comparisons between these therapies have been limited, prompting researchers to evaluate their relative effectiveness and safety in a real-world primary care setting.

Full study details.

Nearly 18 million US women aged 45 to 64 overdue for cancer screening, study finds

The findings highlight persistent and widespread gaps in breast, cervical, and colorectal cancer screening uptake among women aged 45 to 6, an age group for which all 3 screenings are currently recommended, and identify access-related factors as key drivers of incomplete screening.

Full details.