Ronald F. Feinberg, MD, PhD

Articles by Ronald F. Feinberg, MD, PhD

I am 28 years old and I've been actively trying to get pregnant for the past 2 years. I recently underwent a laparoscopy by my gynecologist. She told me that I had minimal endometriosis, but that my ovaries and tubes looked normal. She told me that endometriosis is associated with infertility, but I don't really understand the connection.

My gynecologist recently told me that I have polycystic ovary syndrome (PCOS), and that I should try to lose weight before he gives me fertility medications. A friend told me that I should start taking a medicine to help lower my insulin levels. I'm confused about the connection between insulin and PCOS, and why I need to take an insulin-lowering medicine. I am 28 years old, and otherwise in good health.

In women with severe clomiphene-resistant PCOS, we proposed thatthe insulin-lowering agent troglitazone (Rezulin®) could have a positive impact on the ovarian microenvironment by supporting normal follicular growth, ovulation, and successful pregnancy.

I do not advocate starting any particular insulin-sensitizing agent (ISA) unless the benefits outweigh the risks. For short-term use to aid with ovulation induction, Metformin has > been studied in small series of patients.

OBGYN.net Conference CoverageFrom the International PCOSupport Conference and the Women’s Symposium on Polycystic Ovarian Syndrome - San Diego, CA - May 2000

In general, ISAs have not been studied for long term use. The only studies in women with PCOS have related to helping those women ovulate (i.e. short term use).

Latest Updated Articles