Infertility

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In infertile women undergoing therapy with assisted reproductive techniques, such as in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), the use of gonadotropins to achieve multifollicular development is now well established.

The routine transfer of cleavage stage embryos to the patient’s uterus on day 2 or 3 has two inherent drawbacks; firstly the embryo does not reside in the uterus at such time, and secondly, up to the 8-cell stage one is observing a cleaving oocyte, in that the majority of embryonic genes have not been activated.