Pharmacological Meta-Analyses Rarely Report Disclosures

Article

Meta-analyses of pharmacological treatments rarely include information addressing primary study funding and conflicts of interest (COIs) of the authors for the included randomized control trials (RCTs), according to a study published in the March 9 issue of the Journal of the American Medical Association.

TUESDAY, March 8 (HealthDay News) -- Meta-analyses of pharmacological treatments rarely include information addressing primary study funding and conflicts of interest (COIs) of the authors for the included randomized control trials (RCTs), according to a study published in the March 9 issue of the Journal of the American Medical Association.

Michelle Roseman, from McGill University in Montral, and colleagues determined whether meta-analyses of pharmacological treatments in high-impact journals report COIs that are disclosed in the RCTs they include. Twenty-nine meta-analyses of patented pharmacological treatments published between January and October 2009 in five areas of medicine were reviewed to identify study funding disclosure, author financial relationships, and author employment for meta-analyses and their RCTs.

The researchers found that only two meta-analyses reported RCT funding sources, and none reported RCT author-industry relationships or pharmaceutical industry employment. The meta-analyses reviewed covered 509 RCTs, with 318 RCTs reporting funding sources, of which, 69 percent disclosed funding from industry. Of 132 RCTs that reported author financial disclosures, 69 percent had at least one author with a financial relationship to the pharmaceutical industry. In seven of the 29 meta-analyses, all of the included RCTs had at least one form of disclosed COI, but only one reported RCT funding sources, and none reported RCT author-industry ties or employment.

"This study found that meta-analyses of pharmacological interventions published in high-impact medical journals rarely reported the funding sources or author-industry financial ties of included RCTs, even when these sources of COIs were disclosed in RCT reports," the authors write.

One author disclosed a financial relationship with legal firms involved in cases dealing with the pharmaceutical industry.

AbstractFull Text (subscription or payment may be required)

Related Videos
The significance of the Supreme Court upholding mifepristone access | Image Credit: unchealth.org
One year out: Fezolinetant displays patient satisfaction for managing hot flashes | Image Credit: sutterhealth.org
Addressing maternal health inequities: Insights from CDC's Wanda Barfield | Image Credit: cdc.gov
Addressing racial and ethnic disparities in brachial plexus birth Injury | Image Credit: shrinerschildrens.org
Innovations in prenatal care: Insights from ACOG 2024 | Image Credit:  uofmhealth.org.
Unlocking therapeutic strategies for menopausal cognitive decline | Image Credit: uclahealth.org.
Navigating menopause care: Expert insights from ACOG 2024 | Image Credit: mayo.edu.
raanan meyer, md
Related Content
© 2024 MJH Life Sciences

All rights reserved.