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Endometriosis is a disease in which endometrial glands and stroma implant and grow in areas outside the uterus . The most common place to find implants is in the peritoneal cavity, but they can be found in any other place.
Endometriosis is a disease in which endometrial glands and stroma implant and grow in areas outside the uterus . The most common place to find implants is in the peritoneal cavity, but they can be found in any other place. The location and inflammatory response to these lesions are believed to play key role in symptoms and signs associated with endometriosis.
Main theories that explain the etiology of endometriosis: 1) Sampson's theory of transplantation and implantation, through their fallopian tubes into the peritoneum during menstruation (Sampson JA ,1927), 2) Meyer's theory, suggests that metaplasia of the coelomic epithelium is the origin of endometriosis (Meyer R , 1919), and 3) Halban's theory; suggests that distant lesions are established by the hematogenous or lymphogenous spread of active endometrial cells.
Peritoneum and peritoneal fluids:
Is the most extensive serous membrane in the human body, and consists of two layers
Peritoneal fluids arises from plasma and ovarian oxidates, with average volume of 5-20 ml. The peritoneal fluid (PF) is a dynamic environment that links the reproductive and immune systems. It appears likely that endometriotic tissue is influenced by this environment and in turn, the PF is altered by the presence of endometriosis. The result is a cellular mixture rich in cells that can assist the growth and maintenance of endometrial implants as well as inhibition of fertility (Vinatier D,1996).
Role of peritoneal fluid’s cells in endometriosis:
Many cells present in the peritoneal fluids and appear to be play role in endometriosis:
All available data suggest that peritoneal fluid components changes may play an essential role in the interruption of the whole natural processes of ovulation, fertilization and implantation, more investigation must be done to clarify the role of each of these pathological findings and ways of their elimination.
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