Sreya is a PhD student at The University of British Columbia in Vancouver.
Although targeted treatments for neuroproliferative dyspareunia remain a future goal, clinicians can use current findings to counsel patients that differential nerve growth around endometriosis lesions may underlie their experience of deep dyspareunia—with serum NGF biomarkers and upstream mechanistic research identified as key next steps.
A prospective registry study of 180 patients found that PGP9.5 nerve bundle density around posterior pelvic endometriosis lesions was significantly associated with deep dyspareunia but not with other endometriosis-related pain types, validating the proposed subtype of neuroproliferative dyspareunia.
