Malignancy Risks of Neurokinin Receptor Antagonists

What does data from the clinical trials suggest about the incidence of neoplasms with fezolinetant and elinzanetant?

Notes:Across 3 clinical trials, fezolinetant is associated with a small, but higher incidence of endometrial hyperplasia or endometrial malignancy.

There were no cases of endometrial hyperplasia or endometrial malignancy observed with elinzanetant in a long-term safety study.