Neurokinin and Estrogen Balance in Menopausal Hot Flashes for Primary Care

• How can we simplify the physiology of KNDY neurons and roles of NK receptors for better understanding among primary care physicians?

Note: NK3 antagonism targets VMS (hot flashes); NK1 antagonism impacts sleep and night sweats

Note: Fezolinetant, a selective NK3 antagonist, reduces hot flashes

Note: Elinzanetant, in addition to reducing hot flashes (via NK3 antagonism) is also an NK1 antagonist which improves sleep disturbances and night sweats