Fezolinetant Guidelines and Emerging Data on Menopause and Liver Health

• Why was a warning about serious liver injury added to the prescribing information for fezolinetant? (ie, postmarketing case of drug-induced liver injury)

Note: Clarify that when fezolinetant first came out, it had guidelines for baseline liver testing. But in the past month, this was updated- discuss update and what this means for patients/ physicians.

• What baseline hepatic laboratory tests are recommended before patients start fezolinetant, and how often should they be monitored?
• What symptoms or clinical laboratory values indicate that fezolinetant should be discontinued?
• What are important discussion points to address patient concerns on liver health?