Integrating Patient Reported Outcomes to Capture Meaningful Clinical Benefit

This discussion highlights the essential role of patient-reported outcomes in assessing treatment success, since women’s perceptions of reduced awakenings, improved sleep quality, and less severe hot flashes directly influence daytime functioning and help-seeking behavior. Objective polysomnography results in NIRVANA—showing reductions in wakefulness and improved sleep continuity—provide strong corroboration of these subjective gains. The dual confirmation strengthens confidence in the therapy’s impact on real-world quality of life.