Breast Health

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In women with human epidermal growth factor receptor 2 (HER2)-positive early breast cancer, treatment with trastuzumab for one year after chemotherapy is associated with significant disease-free survival at a four-year follow-up, according to a study published online Feb. 25 in The Lancet Oncology.

The American Society of Clinical Oncology has issued updated guidelines for the use of bone-modifying agents (BMAs) in treating breast cancer patients with bone metastases to include a new drug, denosumab, and provide new advice regarding a potentially serious complication of treatment, osteonecrosis of the jaw (ONJ); an overview of the guideline update was published online Feb. 22 in the Journal of Clinical Oncology.

Although mothers with type 1 diabetes are less likely to partially or exclusively breast-feed at two months, diabetes is not an independent risk factor for the initiation and maintenance of breast-feeding, according to a study published in the February issue of Diabetes Care.

Mammography screening for breast cancer may be less accurate among women with a personal history of breast cancer (PHBC), despite a higher underlying cancer rate, relative to women without PHBC, according to a study published in the Feb. 23 issue of the Journal of the American Medical Association.

Initiating mammography at a younger age and screening more frequently than the U.S. Preventive Services Task Force (USPSTF) recommends will likely result in more lives saved, according to a study published in the February issue of the American Journal of Roentgenology.

Saline or silicone gel-filled breast implants my be associated with anaplastic large cell lymphoma (ALCL), the U.S. Food and Drug Administration announced today. The agency requested that health care professionals report any confirmed cases of the disease in women with implants.

Breast arterial calcification may have a role as a specific marker of medial vascular calcification in chronic kidney disease (CKD), and it is significantly increased in end-stage kidney disease (ESKD), according to a study published online Jan. 21 in the Clinical Journal of the American Society of Nephrology.

A Western diet high in fat and cholesterol may be linked to larger, faster-growing tumors that metastasize more easily in mice predisposed to breast cancer, according to a study published in the January issue of the American Journal of Pathology.