MBD2, the gene encoding methyl-CpG-binding domain (MBD)2, is a major methylation related gene and functions as a transcriptional repressor that can specifically bind to the methylated regions of other genes. MBD2 may also mediate gene activation because of its potential DNA demethylase activity.
Five years ago this summer the National Institutes of Health’s stopped early a major portion of the Women’s Health Initiative (WHI), a large and ambitious study to address the most common causes of death, disability and impaired quality of life in postmenopausal women.
Transcriptional Changes Associated with Breast Cancer Occur as Normal Human Mammary Epithelial CellsOvercome Senescence Barriers and Become Immortalized
Most previous studies have focused on evaluating the association between circulating insulin-like growth factor binding protein 3 (IGFBP-3) levels and breast cancer risk. Emerging evidence over the past few years suggests that IGFBP-3 may act directly on mammary epithelial cells.
It has been suggested that hormonal risk factors act predominantly on estrogen receptor and progesterone receptor (ER/PR)-positive breast cancers. However, the data have been inconsistent, especially in younger women.
Gene expression profiling has been successfully used to classify breast cancer into clinically distinct subtypes, and to predict the risk of recurrence and treatment response. The aim of this study was to investigate whether the gene expression profile (GEP) detected in a core biopsy (CB) is representative for the entire tumor, since CB is an important tool in breast cancer diagnosis.
Research published in this week's issue of Nature describes the molecular structure of two cancer-related proteins binding to one another. Scientists identified the biochemical and signaling properties of these molecules using a process called X-ray crystallography.
In a study published today in Europe's leading reproductive medicine journal Human Reproduction1, researchers from New York's Cornell University report the first IVF pregnancy to result from the use of tamoxifen as an ovarian stimulant.
Three Weeks of Two-Drug Chemotherapy as Good as Six Weeks of Triple Chemotherapy
The recognition and description of tumor growth control factors, together with the development of interventions that modulate their biologic activity, represent a major focus for current cancer research, which already has changed the practice of clinical oncology.
Breast cancer is traumatic not only for the women who develop it, but also for the men in their lives. I know. In 1991, my wife was diagnosed, and I found myself along for an unpleasant ride as she had surgery, two months of daily radiation, and six months of biweekly chemotherapy, not to mention the emotional upheaval the disease engenders.
Human MUC1 mucin, a membrane-bound glycoprotein, is a major component of the ductal cell surface of normal glandular cells. MUC1 is overexpressed and aberrantly glycosylated in carcinoma cells. The role MUC1 plays in cancer progression represents two sides of one coin.
Sore breasts can signal the onset of PMS -- that 'ouch' feeling tells some women they're premenstrual more reliably than a calendar. Cyclical breast soreness shouldn't cause concern, according to Women's Health America. However, breast pain doesn't have to be tolerated. Here's how to minimize discomfort, and how to recognize cautionary signs that should send you to your doctor.
Tumor marker tests include a variety of tests for cancer that can be performed on cells of a tissue sample from a newly biopsied or stored tumor. Tumor marker testing provides the patient and oncologist with vital information about the tumor at the cellular level, expanding traditional pathology reports that are based on tumor size, appearance and staging of the disease.
A Catholic doctor shares his thoughts on eary breast cancer detection with a story about its patron saint.
Breast Cancer and Breast Disease
At 30,000 feet, breast cancer awareness is probably not the first thing on an airline passenger’s mind. But Delta Airlines is trying to change all that. Delta’s “Force for Global Good” is offering $2 glasses of pink lemonade to customers and donating all proceeds to The Breast Cancer Research Foundation (BCRF).
This month is National Breast Cancer Awareness Month and so I feel it's an appropriate time to Reflect on my last eighteen months going down that road. I will try not to make this a sad trip but instead a hopeful one for all of us either with the disease or with loved one's going through this journey.
This week on the Women's Forum there have been two posts that have "touched home" for me. I must share with you that I was hesitant at first to answer them. Why, you are probably asking... Well they are Both subjects that I am completely familiar with and yet felt reluctant to open-up about on the forum.
Today I stood on the steps of the State House in Austin, Texas along with a thousand or so other good people who were trying to send a message to Congress to spend more money on Cancer research. We were there to support the March for Cancer taking place in our country's Capital, Washington, DC.
I was sitting in a chair today waiting for my fingernails to dry and started looking through a recent issue of Readers Digest. On page 50 is a true story about a women named Diana Golden and her journey during the last 28 years.
Janet George is a mother of three, grandmother of seven, and a breast cancer survivor. Her story began after a routine mammogram. Janet's mother died of breast cancer, so regular mammograms have always been part of her healthcare. Janet was notified that a small tumor had been found during a routine mammogram, and her cancer was diagnosed after a wire localization biopsy.
Each year, an estimated 200,000 new cases of breast cancer are diagnosed in the U.S., affecting women of all races, from all walks of life. The disease can strike at any time, as the Latina music star Soraya learned when she was diagnosed in 2000 with breast cancer at the young age of 31.
How to know if you're getting good advice about Breast Disease and Breast Cancer
During the past eighteen years in my medical practice, I’ve had a direct impact (I hope a positive impact) on breast cancer treatment for over a thousand women confronting this diagnosis. During this time span the DECISION MAKING process has become increasingly complex.
