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In this chapter, Dr. Owen reviews the diagnosis or cervical insufficiency; patient selection for history-indicated (prophylactic), physical examination-indicated (Emergent), and ultrasound-indicated (urgent) cerclage; placement and removal of cerclagel and adjunctive therapies.

The United States Food and Drug Administration (FDA), under its priority review program, recently approved PerjetaTM (pertuzumab), a HER2/neu receptor antagonist indicated in combination with HerceptinR (trastuzumab), another HER2 therapy, and docetaxel for treatment of HER2-positive metastatic breast cancer (BCa) in women who have not received prior anti-HER2 therapy or chemotherapy for metastatic disease.

Analysis by the United States Food and Drug Administration (FDA) of compounded 17α-hydroxyprogesterone caproate (17P) shows the samples meet the potency and total purity standards for Makena, the branded version of the drug. Testing was done on 16 samples of bulk 17P active pharmaceutical ingredients (API) in response to questions from K-V Pharmaceuticals, Makena’s sponsor, about potency and purity of the compounded product.

Scientists are testing a procedure that allows women with a genetic disorder conceive without passing the disease on to their children, and it involves using DNA from a "third parent." Is it ethical?

Estrogen-deficient women who have had a hysterectomy with or without ovarian preservation are more likely to have arterial stiffness than estrogen-deficient women who have not had a hysterectomy, according to results of a new study conducted at the University of Colorado School of Medicine in Denver.

The number of cases of cephalosporin-resistant gonorrhea is increasing, according to a recent report issued by the World Health Organization. Neisseria gonorrhoeae, the bacteria that causes the infection, has already developed resistance to other common antibiotics, and cephalosporins have become the last line of defense against the infection.

The U.S. Preventive Services Task Force has issued draft recommendations for postmenopausal hormone therapy for the primary prevention of chronic conditions, such as heart disease, stroke, dementia, hip fracture, and breast cancer.

In a highly critical re-analysis of the Women’s Health Initiative (WHI) study of 2002, the results of which prompted safety fears about hormone replacement therapy (HRT) significantly increasing the risk of breast cancer, it was concluded that the weight of evidence supports benefits over risks for use of HRT in women with severe symptoms of menopause or other conditions.

In anovulatory women with polycystic ovary syndrome (PCOS), one-time use of progestin to induce withdrawal bleeding before ovulation induction may decrease the odds of conception and live birth, according to a new study conducted by researchers for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NIHCD) Cooperative Reproductive Medicine Network (RMN).

Long-acting reversible contraceptives (LARCs) are significantly more effective than oral contraceptive pills, rings, or patches in preventing unintended pregnancy in adolescent girls and young women, a large prospective cohort study from Washington University School of Medicine reports.