In "Evaluating Newer Non-Hormonal Therapies for VMS," our panel explores the similarities and distinctions between fezolinetant and elinzanetant as NK receptor antagonists, with a focus on how these differences inform clinical decision-making for a patient with inadequate response to MHT.
In this episode, "Addressing Cognitive Symptoms and Transitioning from MHT to Non-Hormonal Therapy for VMS," two menopause experts explore the clinical and societal burden of cognitive dysfunction in menopausal women, and the decision-making process around transitioning from hormonal to non-hormonal therapy.
This episode, titled "A Case of a 51-Year-Old Woman with VMS and Inadequate Response to MHT," features panelists examining the clinical approach to a patient presenting with persistent moderate to severe VMS following what appears to be an inadequate response to menopause hormone therapy.
Bladder symptoms in patients seeing ob-gyns require a multifactorial evaluation framework that builds patient timelines across medications, hormonal changes, pelvic floor function, and environmental exposures, whereas counseling on microplastic exposure during pregnancy should emphasize practical, evidence-based reduction strategies rather than fear, according to Aleece Fosnight, MSPAS, PA-C.
Practical strategies including waiting-room symptom questionnaires and a direct, symptoms-based conversational approach can help ob-gyns incorporate HSDD screening into time-limited visits, whereas the cultural visibility of "female Viagra" as a search term represents an underutilized entry point for patient education and provider-initiated conversations.
A meta-analysis of 53 studies found that Black women had 53% lower odds of HRT use than White women, and that diabetes, obesity, stroke, and VTE history were each associated with lower uptake—findings that point to both racial inequities and potentially overcautious prescribing in women with cardiovascular risk factors who may benefit from individualized assessment.
Susan Loeb-Zeitlin, MD, FACOG, breaks down the recently-updated ACOG guidance related to postmenopausal bleeding.
Melissa Loseke, DO, highlighted evidence that testosterone therapy in women may improve energy, mood, cognition, and cardiometabolic markers beyond sexual function.
Learn how clinicians counsel menopause hormone therapy: debunk WHI myths, set expectations for relief, weigh risks, and refer for heart screening.
Learn how clinicians counsel hesitant patients on menopause hormone therapy—debunk WHI myths, set expectations, and tailor safety with referrals.
Learn how perimenopause shifts heart and clot risks, and why transdermal estrogen plus progesterone may be safer for women with BMI and hypertension.
Learn how clinicians monitor liver safety for new hot-flash therapies and why teamwork improves menopause care during cancer treatment.
For patients who express hesitancy about receiving multiple vaccines at once, Sonneveld pointed to the layered reassurance the evidence base now provides.
A novel methylation signature may help identify patients unlikely to respond to progestin therapy, according to Hugh Taylor, MD.
Genevieve Neal-Perry, MD, PhD, highlights that phase 4 real-world data confirm that fezolinetant significantly reduces VMS bother, particularly in high-burden groups such as Black women and patients with obesity.
Progressive menstrual pain should prompt earlier evaluation for endometriosis to prevent missed opportunities and delayed care, Hugh Taylor, MD, explained.
David Shalowitz explains why experts now recommend a dual approach for most patients with postmenopausal bleeding due to limitations in ultrasound accuracy.
Learn how clinicians monitor liver safety for hot-flash therapies and why multidisciplinary teams improve menopause care during cancer treatment.
Learn how elinzanetant eases hot flashes fast, improves sleep, and supports adherence to life-saving endocrine therapy through shared decisions.
Explore nonhormonal menopause relief for breast cancer survivors—sleep-focused strategies, NCCN guidance, and new elinzanetant data.
Expanding access and clinician education may enhance effectiveness of HPV self-collection programs.
Earlier initiation of conservative therapies may improve outcomes and reduce the need for advanced treatment in stress urinary incontinence.
At ACOG, David Shalowitz, MD, highlighted the biggest takeaways from April's updated guidance on postmenopausal bleeding.
Early postpartum visits were associated with a 44% reduction in acute care use among patients with SUD, regardless of care model.
Severe menopausal hot flashes disrupt sleep in a breast cancer survivor on anastrozole—explore safe, effective nonhormonal options.
Clinicians unpack hot flashes’ real-life toll and compare lifestyle, hormone, nonhormone, and emerging NK3 therapies to tailor menopause relief.
An at-home menstrual blood diagnostic platform in development may enable earlier, noninvasive detection of endometriosis.
Sameena Rahman, MD, FACOG, highlights that renaming PCOS to PMOS is vital for recognizing the condition as a systemic metabolic disorder rather than a simple ovarian issue.
Elizabeth Alderman, MD, and Julie Samuels explain new research detailing what data exists for period poverty in high-income countries, as well as the lack of data on established interventions.
Eduardo Lara-Torre, MD, FACOG, explains that the unbundling of obstetric codes on January 1, 2027, will allow physicians to bill for each visit individually rather than receiving a single bundled payment.
