Progestins Used in Combined Hormonal Contraceptives
August 7th 2025Panelists discuss how progestins have evolved from early norethindrone compounds through more potent but androgenic levonorgestrel to newer options such as drospirenone and dienogest, each offering different benefits for cycle control, noncontraceptive effects, and adverse effect profiles.
Forms of Estrogens in Combined Hormonal Contraceptives
August 7th 2025Panelists discuss how most combined hormonal contraceptives contain ethinyl estradiol for its long half-life and cycle control benefits, while newer natural estrogens such as estradiol and estetrol offer different tissue selectivity and potentially reduced liver impacts.
OASIS-3 Trial and Bone Mineral Density Subanalysis: Design, Methods, and End Points
August 4th 2025An expert discusses how the OASIS-3 trial was designed as a 52-week placebo-controlled study in postmenopausal women with moderate to severe vasomotor symptoms, including experimental bone health end points.
Neurokinin Therapies for VMS: MOAs and Potential Bone Health Implications
August 4th 2025An expert discusses how neurokinin receptor antagonists like fezolinetant (NK3) and elinzanetant (NK1/NK3) work in the hypothalamus to reduce vasomotor symptoms, with elinzanetant showing promising skeletal benefits.
Risk Factors for Postpartum Depression
Panelists discuss how certain patients require closer monitoring, including those with previous mental health histories, recent losses, childhood trauma, or abrupt medication cessation, while emphasizing the importance of continuing necessary psychiatric medications during pregnancy and lactation through proper risk-benefit discussions.
Impact on Quality of Life in Postpartum Depression
Panelists discuss how untreated perinatal mood disorders create cascading effects that impact breastfeeding, partner relationships, and child development, and can lead to adverse childhood experiences with long-term consequences for both mothers and children across generations.
Exploring Contraceptive Options for Younger Women
July 31st 2025Panelists discuss how younger women (18-24) most commonly use condoms and oral contraceptive pills due to factors like less frequent sex, dual protection needs, and access issues, while emphasizing that individual preferences matter more than age when counseling patients.
Clinical Considerations in Contraceptive Choice and Use of Low-Dose Estrogen Formulation
July 31st 2025Panelists discuss how combined hormonal contraceptives come in three main forms (pills, patches, and rings) and provide a comprehensive overview of all available contraceptive methods including long-acting reversible contraceptives, barrier methods, and emergency contraception.
Therapies for Vasomotor Symptoms and Their Effects on Bone Mineral Density
July 28th 2025An expert discusses how estrogen remains the most effective treatment for vasomotor symptoms while also benefiting bone density, though alternative treatments like paroxetine and fezolinetant lack bone health benefits.
Recognizing and Differentiating Postpartum Depression
Panelists discuss how perinatal mood and anxiety disorders can occur throughout pregnancy and postpartum periods, with symptoms varying based on timing and requiring differentiation from other conditions like obsessive-compulsive disorder, posttraumatic stress disorder, and panic disorder through careful assessment of presenting symptoms.
Defining Postpartum Depression
Panelists discuss how postpartum depression differs from the normative “baby blues” experience, with postpartum depression being more persistent, severe, and functionally impairing compared with the temporary emotional fluctuations of baby blues that resolve within 2 weeks.
Lead Investigator Perspectives on the Future of VMS Management
July 4th 2025A panelist emphasizes that the OASIS 4 findings, with those of prior OASIS studies, strongly support the use of this drug class for managing vasomotor symptoms (VMS) in patients with breast cancer receiving endocrine therapy and highlights the need for future research in underserved populations such as men with breast cancer and those with metastatic disease.
Hepatic Concerns: What OB/GYNs Should Know From OASIS 4
July 4th 2025A panelist explains that although liver function was closely monitored due to potential concerns about the investigational therapy and concurrent endocrine treatments, no serious hepatotoxicity was observed during the trial. However, continued monitoring in longer-term and real-world settings remains important to confirm the treatment’s liver safety profile.
Lead Investigator Reviews Early Safety Signals from Novel VMS Agents
July 4th 2025A panelist notes that although the treatment was generally well tolerated—with fatigue, somnolence, and diarrhea being the most common adverse effects—long-term data on breast cancer outcomes such as recurrence and survival are still lacking, underscoring the need for extended follow-up and real-world evidence to fully assess long-term safety and efficacy.
Improving Patient Tolerability: Elinzanetant in Breast Cancer Care
June 27th 2025A panelist emphasizes that effectively managing endocrine therapy adverse effects—particularly vasomotor symptoms—can significantly improve treatment adherence, which is critical for reducing recurrence risk and improving survival in patients with breast cancer.
Rapid Relief: Quality-of-Life Improvements Observed in Recent VMS Trials
June 27th 2025A panelist shares that secondary results from the trial showed early and sustained improvements in sleep and quality of life, underscoring the therapy’s potential to enhance endocrine treatment adherence by alleviating vasomotor symptoms (VMS) that often lead to poor adherence in patients with breast cancer.
OASIS-4 in Focus: Lead Investigator Reviews Trial Design
June 20th 2025A panelist highlights that at ASCO 2025, a landmark phase 3 trial showed a new treatment significantly reduced moderate-to-severe hot flashes in patients with breast cancer receiving endocrine therapy, with rapid and sustained symptom relief and high patient continuation rates over 2 years.
How New Pathways Are Easing Vasomotor Symptoms in Breast Cancer Care
June 20th 2025A panelist explains that although hormone replacement therapy is contraindicated in patients with breast cancer due to recurrence risks, new nonhormonal treatments targeting neurokinin receptors in the brain offer promising relief for vasomotor symptoms without interfering with endocrine therapy.