Bone Density’s Role in VMS Treatment and Neurokinin Therapy
August 25th 2025An expert discusses how the ideal vasomotor symptom treatment would address both symptoms and bone loss simultaneously, making nonestrogen therapies with skeletal benefits like elinzanetant particularly attractive for patients.
Treatment Options and Monitoring Treatment Response in Postpartum Depression
Panelists discuss how new FDA-approved treatments like zuranolone offer rapid onset options for postpartum depression, while monitoring effectiveness requires regular follow-up, rescreening, symptom assessment, and addressing global factors like sleep support and breastfeeding pressures.
Treatment Barriers and Key Elements of Successful Treatment Plans in Postpartum Depression
Panelists discuss how treatment barriers include limited prescriptive access and long wait times, while successful treatment plans require assessing severity levels, maternal functioning, support systems, and incorporating follow-up care with appropriate interventions based on the patient’s specific needs.
Other Low-Dose Estrogen Combined Hormonal Contraceptive Formulations
August 21st 2025Panelists discuss how the drospirenone/estetrol (E4) pill with 14.2 mg of estrogen provides effective contraception with a long half-life progestin that accommodates typical user behavior, while explaining that milligram vs microgram dosing reflects different estrogen metabolism rather than higher exposure.
Norethindrone Acetate/Ethinyl Estradiol as Ultra–Low-Dose Estrogen Combined Hormonal Contraceptive
August 21st 2025Panelists discuss how the norethindrone acetate/ethinyl estradiol pill with 10 mcg of estrogen became the best-selling branded pill in the US due to its effective 24/2/2 formulation that minimizes bleeding issues through reduced placebo days and low-dose estrogen support.
Sarah Raifman, PhD, MSc, highlights the link between heavy drinking and pregnancy
August 15th 2025A new study using advanced pregnancy preference measures reveals that heavy alcohol use significantly increases the risk of unintended pregnancy, highlighting the need for personalized contraceptive support.
Managing Postpartum Depression in Clinical Practice
Panelists discuss how to manage positive screens through resources like Postpartum Support International, state psychiatric consultation lines, combination therapy approaches, and addressing patient concerns about medication through evidence-based conversations and gradual implementation.
Improving Patient Communication in Postpartum Depression
Panelists discuss how to overcome patient reluctance to discuss postpartum depression through normalization, early conversations during pregnancy, comprehensive screening integration, and addressing stigma by comparing mental health treatment with other medical conditions.
Estrogen Dosing in Combined Hormonal Contraceptives
August 14th 2025Panelists discuss how estrogen dosing selection depends on individual patient factors, including cycle control needs, noncontraceptive goals, estrogen sensitivity, age considerations for bone health, and patient comfort with hormone levels, with most providers using lower doses primarily to address estrogen-related adverse effects.
Patient Profiles for Combined Hormonal and Progestin-Only Contraceptives
August 14th 2025Panelists discuss how ideal candidates for combined hormonal contraceptives are those medically cleared for estrogen use who prefer predictable monthly periods, while progestin-only methods are recommended for patients with estrogen contraindications such as elevated body mass index (BMI) combined with older age or hypertension with migraines.
BMD Biomarker Outcomes With Elinzanetant vs Placebo: Clinical Relevance and Implications
August 11th 2025An expert discusses how elinzanetant showed less bone mineral density decrease, reduced bone turnover markers, and increased total body bone density compared to placebo, suggesting beneficial skeletal effects.
Screening and Referral Recommendations in Postpartum Depression
Panelists discuss how effective screening goes beyond formal tools like the Edinburgh Postnatal Depression Scale to include genuine patient connection, direct questioning about emotional well-being, and clinical observation, while emphasizing the important role pediatricians can play in identifying maternal mental health concerns during frequent baby visits.
Collaborative Role of Providers for Screening, Diagnosis, and Referrals in Postpartum Depression
Panelists discuss how reproductive psychiatry is an evolving subspecialty that requires collaboration between obstetricians, primary care providers, and psychiatrists, with clear guidelines for when to refer patients (such as those with bipolar history, psychosis, or treatment resistance) while building capacity for basic screening and treatment in obstetric settings.
Progestins Used in Combined Hormonal Contraceptives
August 7th 2025Panelists discuss how progestins have evolved from early norethindrone compounds through more potent but androgenic levonorgestrel to newer options such as drospirenone and dienogest, each offering different benefits for cycle control, noncontraceptive effects, and adverse effect profiles.
Forms of Estrogens in Combined Hormonal Contraceptives
August 7th 2025Panelists discuss how most combined hormonal contraceptives contain ethinyl estradiol for its long half-life and cycle control benefits, while newer natural estrogens such as estradiol and estetrol offer different tissue selectivity and potentially reduced liver impacts.
OASIS-3 Trial and Bone Mineral Density Subanalysis: Design, Methods, and End Points
August 4th 2025An expert discusses how the OASIS-3 trial was designed as a 52-week placebo-controlled study in postmenopausal women with moderate to severe vasomotor symptoms, including experimental bone health end points.
Neurokinin Therapies for VMS: MOAs and Potential Bone Health Implications
August 4th 2025An expert discusses how neurokinin receptor antagonists like fezolinetant (NK3) and elinzanetant (NK1/NK3) work in the hypothalamus to reduce vasomotor symptoms, with elinzanetant showing promising skeletal benefits.
Risk Factors for Postpartum Depression
Panelists discuss how certain patients require closer monitoring, including those with previous mental health histories, recent losses, childhood trauma, or abrupt medication cessation, while emphasizing the importance of continuing necessary psychiatric medications during pregnancy and lactation through proper risk-benefit discussions.
Impact on Quality of Life in Postpartum Depression
Panelists discuss how untreated perinatal mood disorders create cascading effects that impact breastfeeding, partner relationships, and child development, and can lead to adverse childhood experiences with long-term consequences for both mothers and children across generations.
Exploring Contraceptive Options for Younger Women
July 31st 2025Panelists discuss how younger women (18-24) most commonly use condoms and oral contraceptive pills due to factors like less frequent sex, dual protection needs, and access issues, while emphasizing that individual preferences matter more than age when counseling patients.
Clinical Considerations in Contraceptive Choice and Use of Low-Dose Estrogen Formulation
July 31st 2025Panelists discuss how combined hormonal contraceptives come in three main forms (pills, patches, and rings) and provide a comprehensive overview of all available contraceptive methods including long-acting reversible contraceptives, barrier methods, and emergency contraception.