A matched cohort study of nearly 14,000 singleton pregnancies found no association between same-day influenza and pertussis vaccination during pregnancy and increased rates of preterm birth, small for gestational age, low birth weight, or any assessed secondary adverse outcome compared with pertussis vaccination alone.
Rachel Sood, NP-C, CDCES, highlights how the FDA clearance of Control-IQ+ provides the clinical proof needed to expand the use of AID systems in T1D pregnancies.
Although targeted treatments for neuroproliferative dyspareunia remain a future goal, clinicians can use current findings to counsel patients that differential nerve growth around endometriosis lesions may underlie their experience of deep dyspareunia—with serum NGF biomarkers and upstream mechanistic research identified as key next steps.
Yeo details the use of PBPK modeling alongside organ-on-a-chip technology to predict fetal drug exposure and optimize the maternal risk-benefit ratio.
A prospective registry study of 180 patients found that PGP9.5 nerve bundle density around posterior pelvic endometriosis lesions was significantly associated with deep dyspareunia but not with other endometriosis-related pain types, validating the proposed subtype of neuroproliferative dyspareunia.
Off-label use of HSDD medications in postmenopausal women is common, highlighting unmet treatment needs and a gap between patient search behavior and clinical terminology.
Institutions can meaningfully reduce racial disparities in urine toxicology testing at delivery by eliminating universal testing and adopting any standardized criteria-based screening protocol—provided the criteria are grounded in clinical evidence rather than demographic variables that function as proxies for race.
Conditions like chorioamnionitis change the pH of the surgical environment, which can prevent local anesthetics from working optimally, according to Beth Ann Clayton.
Moving LiSWT into formal postpartum care guidelines will require randomized controlled trials with adequate sample sizes, defined treatment parameters, long-term follow-up, and dedicated safety data in lactating patients, with cost-effectiveness analysis also identified as a priority research direction.
Scott Sullivan, MD, describes a new strategy of training ER staff in hospitals without OB services to manage "drop-in" obstetric emergencies through simulation and remote support.
According to Amy Sarma, MD, moving beyond episodic office visits to multimodality care strategies is essential for reducing adverse cardiovascular outcomes in high-risk patients.
Scott Sullivan, MD, highlights that a third of Virginia is a maternity desert, creating even more severe gaps for patients requiring maternal-fetal medicine.
MMRC data highlight that preventing pregnancy-related infection deaths requires multilevel interventions spanning patient education, provider training, and system readiness, with the AIM obstetric sepsis bundle representing a practical framework while broader outcomes evidence remains limited.
Investigators behind a national EHR study of perinatal GLP-1 RA prescribing acknowledge that the data cannot distinguish inadvertent early-pregnancy exposure from planned preconception discontinuation, and call for deeper, outcomes-focused research to build on the prescribing trends they identified.
Natalia C. Llarena, MD, FACOG, highlights the importance of clinical diagnosis and earlier symptom recognition for endometriosis to help patients find relief faster.
LiSWT may offer a noninvasive option for postpartum pelvic pain, with potential benefits across both chronic and earlier-stage scar-related dysfunction.
In this discussion, Ramu Perni, MD, MBA, details the benefits of using a non-invasive prenatal red blood cell fetal antigen test for pregnancies affected by or at risk for HDFN.
The successful implementation of a privacy-centered, iPad-based substance use screening tool on labor and delivery required multiyear planning, cross-disciplinary staff education, and close collaboration with institutional informatics teams, with formal patient experience assessment planned as a next step.
According to Karen Yeo, PhD, the use of 100 to 200 PBPK models is moving drug administration toward a more personalized, informed decision-making process for pregnant women.
In this video from the 2026 American College of Cardiology Annual Scientific Session & Expo, Amy Sarma, MD, details associations of cardiovascular disease and menopause.
Reducing pregnancy-related infection deaths will require interdisciplinary care protocols, expanded postpartum access points, and broad-based sepsis education across specialties, according to MMRC data showing that most decedents had a health care encounter within 1 week of death.
Azad and colleagues at Columbia University found that drug overdose, homicide, and suicide are the leading causes of death among pregnant and postpartum women.
Adnan I. Qureshi, MD, advocates for the integration of neurologists into obstetric teams to manage the increased stroke risk among pregnant persons with a previous stroke.
Simon highlights the "seamless handoff" between FQHCs and OB hospitalists as a vital mechanism for maintaining delivery access in rural and underserved communities.
A before-and-after cohort study of more than 18,000 patients found that universal aspirin 162 mg dispensation at the first prenatal visit was associated with a 29% reduction in preeclampsia with severe features, with benefit observed across patients with and without chronic hypertension and no increase in hemorrhagic complications.
Adnan I. Qureshi, MD, calls for a multidisciplinary action plan that integrates neurologists into obstetric teams to manage increased recurring stroke risk in pregnancy.
Clinicians evaluating women with new or worsening urinary incontinence should consider thyroid dysfunction—especially hypothyroidism—as a potential contributing factor, with overflow symptoms and systemic hypothyroid signs prompting laboratory evaluation and a comprehensive management approach.
Alla Vash-Margita, MD, FACOG, details how identifying differentially expressed microRNAs in 13- to 26-year-olds could provide a pathway for early detection of endometriosis.
A 4857-patient international RCT found that a single postpartum infusion of IV ferric carboxymaltose was superior to twice-daily oral iron in achieving a non-anemic hemoglobin level at 6 weeks, with sustained hemoglobin benefit through 6 months across all regions studied.
Clinical Case 5 Adjusting Thyroid Replacement Therapy after Discontinuing Estrogen
