Gynecologic Oncology

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Mutations in the PALB2 gene may be associated with a significant increase in the risk of breast cancer, according to a recent study in The New England Journal of Medicine. PALB2 binds to BRCA2-a gene that confers increased lifetime risk of developing breast or ovarian cancer-and likely permits its stable nuclear localization and accumulation.

An analysis of minimally invasive hysterectomies performed at multiple institutions over a 7-year period shows that one in every 368 women who underwent morcellation had uterine cancer. According to the investigators, the study also reveals an association between advanced age and increasing prevalence of underlying cancer and endometrial hyperplasia in these patients.

Institutions around the country have responded to an FDA advisory by discouraging or banning power morcellation of uterine fibroids. Innovative methods of contained morcellation are now called for.

A new analysis of data from a nationwide hospital-based dataset shows that black women have higher odds of being diagnosed with triple-negative breast cancer-a subtype associated with poorer prognosis-than do white women, regardless of socioeconomic status (SES). The report was published in the June issue of Breast Cancer Research and Treatment.