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Mutations in the PALB2 gene may be associated with a significant increase in the risk of breast cancer, according to a recent study in The New England Journal of Medicine. PALB2 binds to BRCA2-a gene that confers increased lifetime risk of developing breast or ovarian cancer-and likely permits its stable nuclear localization and accumulation.

Menopausal hot flashes may be more bothersome in women who drink caffeine, according to results of a 6-year cross-sectional survey published in Menopause.

“Dosing of oxytocin and timing of level of increase in dose has been the subject of many scientific publications,” noted study coauthor and Contemporary OB/GYN editorial board member Haywood Brown, MD.

The ACP’s Clinical Guideline advising against pelvic examinations for the detection of pathological conditions in asymptomatic, nonpregnant, adult women is unfounded, ill timed, and ill considered.

Vulvovaginal disorders in prepubertal girls-including vulvovaginitis, lichen sclerosus, labial adhesions, urethral prolapse, and genital ulcers-are common and can be managed on an outpatient basis by a skilled clinician.

Rates of human papillomavirus (HPV) vaccination in adolescents remain low, 8 years after the Advisory Committee on Immunization Practices (ACIP) recommended routine use of the vaccine in girls aged 11 to 12 years, according to a recent report in the Centers for Disease Control’s (CDC) Morbidity and Mortality Weekly Report.

An analysis of minimally invasive hysterectomies performed at multiple institutions over a 7-year period shows that one in every 368 women who underwent morcellation had uterine cancer. According to the investigators, the study also reveals an association between advanced age and increasing prevalence of underlying cancer and endometrial hyperplasia in these patients.