Obstetrics

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Protocol 5 - In this protocol, Norton reviews the pathophysiology of fetal aneuploidy and the wide range of tests for it. Included are perspectives on cell-free DNA testing, first-trimester combined screening, nuchal translucency (NT) sonography, and pregnancy-associated plasma protein A (PAPP-A) and human chorionic gonadotropin (hCG), as well as quad marker screening in the second trimester in appropriate cases, and combined first- and second-trimester screening.

Because many groups have a stake in newborn screening, “Who will take responsibility for integrating varying perspectives to modernize newborn screening?” Bailey pondered. “Funding and auspice will be critical decisions.”

A cross-sectional analysis of the Boston Birth Cohort (BBC) from 1998 to 2016 has found that maternal nativity and duration of United States residence were linked to preeclampsia among non-Hispanic Black women, but not among Hispanic and non-Hispanic White women, after adjusting for sociodemographic and cardiovascular risk factors.